Nebido is a brand name for a long-acting injectable form of the androgen and anabolic steroid, testosterone undecanoate. It is a legally manufactured and medically regulated medication used for hormone replacement therapy (HRT). It is distinct from unregulated, illicit products like those made by underground labs.
Medical uses
Nebido is primarily used to treat male hypogonadism, a condition in which the body does not produce enough testosterone.
Symptoms of hypogonadism can include:
Symptoms of hypogonadism can include:
- Erectile dysfunction and low libido
- Infertility
- Tiredness and depressive moods
- Reduced bone and muscle mass
- Hot flushes and sweating
Nebido is also sometimes used in masculinizing hormone therapy for transgender men.
How it works
Nebido contains testosterone undecanoate in an oil-based solution that is administered via a deep intramuscular injection.
- Gradual release: After injection, the compound is gradually released from the muscle “depot” into the bloodstream.
- Long half-life: This long-acting formulation provides stable testosterone levels over an extended period.
- Less frequent dosing: The injections are typically given every 10 to 14 weeks, making it a more convenient option than shorter-acting testosterone therapies.
Administration
The first injection interval may be shorter (e.g., after six weeks) to allow for testosterone levels to reach the therapeutic range more quickly. A doctor or nurse must administer Nebido, and patients are monitored regularly to ensure proper hormone levels.
Side effects
As with any medication, Nebido can cause side effects. The most frequently reported are acne and pain at the injection site.
Other potential side effects include:
- Increased red blood cell count
- Weight gain
- Hot flushes
- Prostate enlargement
- Mood disturbances (e.g., depression, anxiety, aggression)
- Headache and dizziness
- Cardiovascular issues
- Liver function changes
- Pulmonary oil microembolism: A rare but serious side effect involving the oil solution entering the lungs, causing symptoms like coughing, shortness of breath, and chest pain
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